Weight Loss Rx & Services: Best Practices

• Purchase your Weight Loss drugs from conventional pharmacies that fill FDA approved prescriptions. CVS, Walgreens, Walmart, Kroger, H-E-B, Randall's, etc.

• Weight Loss drugs purchased from conventional pharmacies are often auto-substantiated, no receipts required.

• If your medical plan does not cover weight loss drugs, purchase your weight loss drugs direct from the manufacturer. See below.

• Weight Loss drugs purchased direct from the manufacturer may not auto-substantiate as often as purchases from conventional pharmacies, but manufacturer purchases will not require a Letter of Medical Necessity.

• Avoid purchasing weight loss drugs from compound pharmacies, unless you are prepared to submit a Letter of Medical Necessity. Compound prescriptions are not FDA approved. A Letter of Medical Necessity will always be required and be valid for one-year.

• Weight loss drugs administered under clinical conditions or by a licensed healthcare professional in their office are eligible weight loss services, but will still require a Letter of Medical Necessity.

Weight loss prescriptions are FSA eligible. Follow this advice to maximize your dollars and time.

Weight Loss Drug Manufacturers*

• Novo Nordisk: Ozempic & Wegovy

• Eli Lilly: Mounjaro & Zepbound

Largest Weight Loss Manufacturers *including diabetes drugs for off label use

Compound Pharmacies

• Hims & Hers** (can now sell FDA-approved Ozempic)

• Ro Health** (can now sell FDA-approved Zepbound)

• Empower Pharmacy

• LifeMD

• Calibrate Health

• Noom Med / Noom

• Henry Meds

• MEDVi

• SkinnyRx

• Shed

Compound Pharmacies do not sell FDA approved weight loss drugs. These online pharmacies are popular alternatives because they market themselves as safe and less expensive. The FDA is issuing warning letters to many of these pharmacies about misleading marketing practices.

Helpful Resources

• IRS FAQ: Nutrition, Wellness, and General Health (Updated January 15, 2026)

• IRS Publication 502: Medical & Dental Expenses (2025 Returns)

• IRS Publication 969: Health Savings Accounts & Other Tax-Favored Health Plans (2025 Returns)

Learn More